Drug Classification:

Sertraline belongs to the class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is widely used as an antidepressant and is also effective in treating anxiety disorders, obsessive-compulsive disorder (OCD), panic disorder, and post-traumatic stress disorder (PTSD).

Formulations:

• Sertraline Hydrochloride Tablets:
  • Strength: Available in 50mg tablets (packed in 30’s) and 100mg tablets (packed in 20’s).
  • Product Form: Oral tablets for easy administration.

Indications:

Sertraline Hydrochloride Tablets are indicated for the following conditions:

• Major Depressive Disorder (MDD): Treatment of MDD, characterized by persistent feelings of sadness and loss of interest or pleasure in activities.
• Obsessive-Compulsive Disorder (OCD): Management of OCD, a mental health disorder characterized by obsessions and compulsions.
• Panic Disorder: Treatment of panic disorder, marked by recurrent panic attacks and associated symptoms.
• Social Anxiety Disorder: Management of social anxiety disorder, characterized by excessive fear of social situations.
• Post-Traumatic Stress Disorder (PTSD): Management of PTSD, a mental health condition triggered by a traumatic event.

Usage:

• Sertraline Hydrochloride Tablets should be taken orally, usually once daily, with or without food.
• It is essential to follow the prescribed dosage and duration of treatment as directed by your healthcare provider.
• Do not abruptly discontinue sertraline without consulting your healthcare provider, as discontinuation symptoms may occur.

Dosage:

• The recommended starting dose of sertraline for adults is usually 50 mg once daily, with adjustments made by the healthcare provider based on individual response and tolerability.
• The dosage may be increased gradually, up to a maximum of 200mg per day for certain conditions.
• Elderly patients or those with hepatic or renal impairment may require lower starting doses.

Pharmacokinetics:

• Sertraline is well absorbed after oral administration, with peak plasma concentrations achieved within 4 to 8 hours.
• It undergoes hepatic metabolism primarily via the cytochrome P450 enzyme system, mainly CYP2C19 and CYP2B6.
• The elimination half-life of sertraline is approximately 24 to 36 hours, allowing for once-daily dosing.

Pharmacodynamics:

• As an SSRI, sertraline works by selectively inhibiting the reuptake of serotonin (5-HT) at the synaptic cleft, thereby increasing serotonin levels in the brain.
• By enhancing serotonin neurotransmission, sertraline helps alleviate symptoms of depression, anxiety, and other related disorders.

Side Effects:

• Common side effects of Sertraline Hydrochloride Tablets may include nausea, diarrhea, insomnia, dizziness, dry mouth, and sexual dysfunction.
• Some individuals may experience weight changes, sweating, tremors, or headache.
• Rare but serious side effects may include serotonin syndrome, suicidal ideation, and hyponatremia.
• It is important to report any unusual symptoms or adverse reactions to your healthcare provider promptly.

Trust in the efficacy and safety of Sertraline Hydrochloride Tablets from AIT Pharmaceuticals Division. We are committed to providing high-quality medications to improve the lives of our patients. For more information, please visit our website or consult your healthcare provider.