Description

Drug Classification:

Simvastatin belongs to the class of medications known as statins, which are lipid-lowering agents. Statins work by inhibiting the enzyme HMG-CoA reductase, thereby reducing the production of cholesterol in the liver and promoting the clearance of low-density lipoprotein (LDL) cholesterol from the bloodstream.

Formulations:

• Simvastatin Tablets:
  • Strengths: Available in 20mg, 40mg, and 80 mg formulations.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each.

Indications:

Simvastatin Tablets are indicated for the:

• Treatment of primary hyperlipidemia (elevated levels of cholesterol and triglycerides) to reduce total cholesterol, LDL cholesterol, and apolipoprotein B levels.
• Reduction of the risk of cardiovascular events, including myocardial infarction, stroke, and coronary revascularization procedures, in patients with established coronary heart disease, diabetes, or other risk factors.

Usage:

• Simvastatin Tablets should be taken orally, with or without food, as directed by a healthcare professional.
• The dosage regimen may vary depending on the patient’s lipid profile, cardiovascular risk factors, and individual response to therapy.
• Regular monitoring of lipid levels and liver function tests is recommended during treatment with Simvastatin to assess treatment efficacy and detect any potential adverse effects.

Dosage:

• The recommended starting dose of Simvastatin is typically 20-40 mg once daily in the evening.
• Dosage adjustments may be made based on the patient’s lipid levels and response to treatment, with a maximum recommended dose of 80mg per day for certain patient populations.
• Dosage should be individualized and titrated carefully to achieve optimal lipid control while minimizing the risk of adverse effects.

Pharmacokinetics:

• Simvastatin is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver, where it is converted to its active form, simvastatin acid.
• Simvastatin acid exerts its lipid-lowering effects by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.

Pharmacodynamics:

• By inhibiting cholesterol synthesis and promoting the clearance of LDL cholesterol from the bloodstream, Simvastatin helps reduce total cholesterol, LDL cholesterol, and triglyceride levels, while increasing high-density lipoprotein (HDL) cholesterol levels.
• These lipid-modifying effects contribute to the reduction of atherosclerotic plaque formation and the risk of cardiovascular events in high-risk patients.

Side Effects:

• Common side effects associated with Simvastatin therapy may include headache, myalgia (muscle pain), gastrointestinal disturbances (nausea, diarrhea, constipation), and fatigue.
• Rare but serious adverse effects such as myopathy (muscle damage), rhabdomyolysis (severe muscle breakdown), and hepatotoxicity (liver damage) may occur and require prompt medical attention.

Experience the proven efficacy and cardiovascular benefits of AIT Pharmaceuticals Division’s Simvastatin Tablets. For more information, please contact us. We are dedicated to promoting heart health and enhancing patient well-being through our pharmaceutical products.