Drug Classification:

Tizanidine belongs to the class of medications known as centrally acting alpha-2 adrenergic agonists. It works by inhibiting nerve signals that cause muscles to tighten, thereby reducing muscle spasticity and improving mobility.

Formulations:

• Tizanidine Tablets:
  • Strength: Available in 2mg and 4mg tablets
  • Product Form: Oral tablets for convenient administration
  • Packing Specifications: Each pack contains 10 tablets for ease of use

Indications:

Tizanidine tablets are indicated for the management of:

• Muscle spasticity associated with multiple sclerosis (MS)
• Muscle spasms caused by spinal cord injuries or diseases
• Musculoskeletal conditions such as back pain and neck pain

Usage:

• Tizanidine tablets should be taken orally with or without food, as directed by your healthcare provider.
• It is essential to follow the prescribed dosage and frequency of administration to achieve optimal therapeutic outcomes.
• Do not abruptly discontinue Tizanidine therapy without consulting your doctor, as sudden withdrawal may lead to rebound muscle spasms or other withdrawal symptoms.

Dosage:

• The recommended dosage of Tizanidine tablets may vary depending on the severity of the muscle spasticity and individual patient response.
• The usual starting dose is 2mg to 4mg taken orally every 6 to 8 hours, with a maximum daily dose of 36mg.
• Dosage adjustments may be necessary based on your medical condition and response to treatment.

Pharmacokinetics:

• Absorption: Tizanidine is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours.
• Distribution: The drug is extensively distributed throughout the body, with a large volume of distribution.
• Metabolism: Tizanidine undergoes extensive hepatic metabolism, primarily via the cytochrome P450 enzyme system.
• Elimination: The elimination half-life of Tizanidine is approximately 2.5 hours, with the majority of the drug and its metabolites excreted in the urine.

Pharmacodynamics:

• Tizanidine exerts its muscle relaxant effects by binding to alpha-2 adrenergic receptors in the central nervous system, leading to a reduction in muscle tone and spasticity.

Side Effects:

• Common side effects of Tizanidine tablets may include:
  • Drowsiness, dizziness, and fatigue
  • Dry mouth, nausea, and constipation
  • Weakness, blurred vision, and headache
• Serious adverse reactions such as liver injury and hypotension may occur, although they are rare.

Experience the effectiveness and reliability of AIT Pharmaceuticals Division’s Tizanidine Range for the management of muscle spasticity. For more information, please contact us. We are committed to providing superior pharmaceutical solutions to healthcare professionals worldwide.