Description

Formulations:

• Tramadol HCl Liquid Ampules:
  • Strength: Each ampule contains 100 mg of Tramadol
  • Product Form: Liquid solution for injection
  • Packing Specifications: Each pack contains 5 ampules for convenient administration

Indications:

Tramadol is indicated for the management of moderate to severe pain, including:

• Acute pain following surgery or injury
• Chronic pain conditions such as osteoarthritis or neuropathic pain
• Cancer-related pain

Usage:

• Tramadol Liquid Ampules are intended for intravenous or intramuscular administration by healthcare professionals.
• The choice of route of administration and dosage regimen should be individualized based on the patient’s pain intensity, medical history, and response to treatment.

Dosage:

• The recommended dosage of Tramadol for adults is typically 50 to 100 mg administered every 4 to 6 hours as needed for pain relief.
• Dosage adjustments may be necessary in elderly patients, patients with renal or hepatic impairment, and those at risk of respiratory depression.
• Maximum daily doses should not exceed 400 mg in adults.

Pharmacokinetics:

• Absorption: Tramadol is well absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours. Bioavailability is approximately 70%.
• Distribution: Tramadol has a large volume of distribution and crosses the blood-brain barrier, exerting its analgesic effects centrally.
• Metabolism: Tramadol undergoes hepatic metabolism via various pathways, including CYP2D6 and CYP3A4 enzymes, resulting in active metabolites.
• Elimination: Tramadol and its metabolites are primarily excreted renally. The elimination half-life of Tramadol is approximately 6 hours.

Pharmacodynamics:

• Tramadol exerts its analgesic effects primarily through its opioid activity, binding to μ-opioid receptors in the central nervous system. It also inhibits the reuptake of serotonin and norepinephrine, contributing to its analgesic efficacy.

Side Effects:

• Common side effects of Tramadol may include:
  • Nausea and vomiting
  • Constipation
  • Dizziness
  • Drowsiness
  • Headache
• Serious adverse reactions such as respiratory depression, addiction, and serotonin syndrome may occur, particularly with high doses or concomitant use of other serotonergic medications.

Experience the effectiveness and reliability of AIT Pharmaceuticals Division’s Tramadol Range for the management of pain. For more information, please contact us. We are committed to providing exceptional pharmaceutical solutions to meet the needs of healthcare professionals and their patients.