Description

Formulations:

• Tramadol + Paracetamol Tablets:
  • Strength: Each tablet contains Tramadol 37.5 mg and Paracetamol 325 mg
  • Product Form: Oral tablets for convenient administration
  • Packing Specifications: Each pack contains 10 tablets

Indications:

Tramadol + Paracetamol tablets are indicated for the relief of moderate to severe acute pain, such as:

• Post-operative pain
• Musculoskeletal pain
• Dental pain
• Neuropathic pain
• Pain associated with trauma or injury

Usage:

• Tramadol + Paracetamol tablets should be taken orally with a full glass of water, with or without food, as directed by a healthcare professional.
• It is important to adhere to the prescribed dosage regimen and not exceed the recommended dose or duration of treatment.

Dosage:

• The usual dosage of Tramadol + Paracetamol tablets for adults is one to two tablets every 4 to 6 hours as needed for pain relief.
• Dosage adjustments may be necessary in elderly patients, patients with renal or hepatic impairment, and those at risk of respiratory depression.

Pharmacokinetics:

• Absorption: Both Tramadol and Paracetamol are well absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours for Paracetamol and 2 to 3 hours for Tramadol.
• Distribution: Tramadol has a large volume of distribution and crosses the blood-brain barrier, exerting its analgesic effects centrally. Paracetamol is distributed widely throughout the body, including the central nervous system.
• Metabolism: Tramadol undergoes hepatic metabolism via various pathways, including CYP2D6 and CYP3A4 enzymes, while Paracetamol undergoes hepatic conjugation.
• Elimination: Both Tramadol and Paracetamol are primarily excreted renally, with elimination half-lives of approximately 6 hours for Tramadol and 2 to 3 hours for Paracetamol.

Pharmacodynamics:

• Tramadol exerts its analgesic effects through binding to μ-opioid receptors and inhibiting the reuptake of serotonin and norepinephrine, thereby modulating pain transmission in the central nervous system.
• Paracetamol is thought to exert its analgesic and antipyretic effects primarily through inhibition of prostaglandin synthesis in the central nervous system.

Side Effects:

• Common side effects of Tramadol + Paracetamol tablets may include:
  • Nausea and vomiting
  • Constipation
  • Dizziness
  • Drowsiness
  • Headache
• Serious adverse reactions such as respiratory depression, addiction, and hepatotoxicity may occur, particularly with prolonged use or high doses.

Experience the combined efficacy and safety of AIT Pharmaceuticals Division’s Tramadol + Paracetamol Range in the management of acute pain. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals worldwide.