Description

Drug Classification:

Venlafaxine as HCl is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). It acts by selectively inhibiting the reuptake of serotonin and norepinephrine in the brain, thereby increasing the levels of these neurotransmitters and alleviating symptoms of depression and anxiety.

Formulations:

• Venlafaxine Hydrochloride Tablets:
  • Strength: Available in 37.5mg tablets (packed in 20’s) and 50mg tablets (packed in 20’s).
  • Product Form: Oral tablets for convenient administration.

Indications:

Venlafaxine Hydrochloride Tablets are indicated for the treatment of:

• Major Depressive Disorder (MDD): Management of depressive episodes associated with MDD, a mood disorder characterized by persistent feelings of sadness, loss of interest or pleasure, and other cognitive and physical symptoms.
• Generalized Anxiety Disorder (GAD): Relief of symptoms associated with GAD, including excessive worry, restlessness, and irritability.

Usage:

• Venlafaxine Hydrochloride Tablets should be taken orally, with or without food, as directed by your healthcare provider.
• It is essential to follow the prescribed treatment regimen and dosage instructions provided by your healthcare provider.
• Do not crush, chew, or break the tablets before swallowing, as this may affect the medication’s efficacy or increase the risk of side effects.

Dosage:

• The recommended starting dose for MDD is 75mg per day, administered in divided doses or as a single daily dose.
• For patients with GAD, the recommended starting dose is 37.5mg per day, with subsequent dose adjustments based on individual response and tolerability.
• Dosage adjustments should be made cautiously under the supervision of a healthcare provider to minimize the risk of adverse effects.

Pharmacokinetics:

• Venlafaxine is well absorbed after oral administration, with peak plasma concentrations achieved within 2 to 3 hours.
• It undergoes extensive hepatic metabolism via the CYP2D6 and CYP3A4 enzyme systems, yielding active metabolites including desvenlafaxine.
• The elimination half-life of venlafaxine and its metabolites ranges from 5 to 11 hours, allowing for once- or twice-daily dosing.

Pharmacodynamics:

• Venlafaxine exerts its therapeutic effects by inhibiting the reuptake of serotonin and norepinephrine in the synaptic cleft, thereby enhancing neurotransmission and modulating mood.
• The dual mechanism of action on both serotonin and norepinephrine pathways contributes to its efficacy in treating depression and anxiety disorders.

Side Effects:

• Common side effects of Venlafaxine Hydrochloride Tablets may include nausea, headache, dizziness, dry mouth, and insomnia.
• Some individuals may experience increased blood pressure, sweating, or sexual dysfunction.
• Serious side effects such as serotonin syndrome or suicidal ideation may occur in rare cases and require immediate medical attention.
• It is important to report any unusual symptoms or adverse reactions to your healthcare provider promptly.

Trust in the efficacy and safety of Venlafaxine Hydrochloride Tablets from AIT Pharmaceuticals Division. We are dedicated to providing innovative solutions for mental health disorders to enhance the lives of our patients. For more information, please visit our website or consult your healthcare provider.