Drug Classification:

Bupropion belongs to the class of medications known as aminoketones and is classified as an atypical antidepressant. Its unique pharmacological profile includes both dopamine and norepinephrine reuptake inhibition, making it effective for treating depression and aiding in smoking cessation by reducing nicotine cravings and withdrawal symptoms.

Formulations:

• Bupropion Tablets:
  • Strength: Each tablet contains 150mg of Bupropion.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Available in packs of 20 tablets.

Indications:

Bupropion Tablets are indicated for the treatment of:

• Major Depressive Disorder (MDD): Bupropion is effective in alleviating symptoms of depression, including persistent sadness, loss of interest or pleasure in activities, changes in appetite or weight, and disturbances in sleep or activity.
• Smoking Cessation: Bupropion aids in smoking cessation by reducing the urge to smoke and minimizing withdrawal symptoms associated with nicotine dependence.

Usage:

• Bupropion Tablets should be taken orally as directed by a healthcare professional.
• For the treatment of depression, the recommended starting dose is usually 150mg once daily, with gradual titration as needed based on individual response and tolerance.
• When used for smoking cessation, the initial dose of Bupropion is typically 150mg once daily for the first 3 days, followed by an increase to 150mg twice daily for the remainder of the treatment period.

Dosage:

• The dosage of Bupropion may vary depending on the indication being treated and individual patient response.
• It is important to follow the prescribed dosage regimen and avoid abrupt discontinuation of treatment to minimize the risk of withdrawal symptoms or recurrence of depression.

Pharmacokinetics:

• Bupropion is well absorbed following oral administration, with peak plasma concentrations reached within 2 to 3 hours.
• It undergoes extensive hepatic metabolism, primarily via the cytochrome P450 enzyme system, to form active metabolites such as hydroxybupropion.
• The elimination half-life of Bupropion and its metabolites is approximately 21 hours, allowing for once or twice-daily dosing to maintain therapeutic plasma concentrations.

Pharmacodynamics:

• Bupropion exerts its antidepressant and smoking cessation effects primarily through the inhibition of dopamine and norepinephrine reuptake in the brain.
• By increasing the levels of these neurotransmitters in synaptic clefts, Bupropion helps regulate mood and reduce cravings associated with nicotine dependence.

Side Effects:

• Common side effects of Bupropion may include dry mouth, headache, nausea, insomnia, and agitation.
• Less frequently observed adverse reactions may include constipation, dizziness, tremor, and weight loss.
• In rare cases, Bupropion may be associated with more serious adverse events such as seizures, serotonin syndrome, or allergic reactions.

Trust in the efficacy and safety of Bupropion Tablets from AIT Pharmaceuticals Division. Whether you are seeking relief from depression or assistance with smoking cessation, our product offers a reliable solution to help you achieve your health goals. For more information, please visit our website or consult your healthcare provider.