Formulations:

• Famotidine Tablets: Available in strengths of 20mg and 40mg, our tablets offer convenient dosing and reliable acid suppression.

Indications:

• Famotidine is indicated for the treatment of:
  • Gastroesophageal reflux disease (GERD)
  • Peptic ulcer disease (duodenal and gastric ulcers)
  • Zollinger-Ellison syndrome
  • Erosive esophagitis
  • Pathological hypersecretory conditions, including systemic mastocytosis

Pharmacokinetics:

• Absorption: Famotidine is well absorbed after oral administration, with peak plasma concentrations reached within 1-3 hours.
• Distribution: It is widely distributed throughout the body, including into the gastric mucosa.
• Metabolism: Famotidine undergoes partial hepatic metabolism, with approximately 30% of the drug excreted unchanged in the urine.
• Elimination: The elimination half-life of famotidine is approximately 2-3 hours in healthy individuals, with renal clearance being the primary route of elimination.

Pharmacodynamics:

• Famotidine exerts its pharmacological effects by competitively blocking the H2 receptors on the gastric parietal cells, thereby inhibiting the secretion of gastric acid. This results in reduced acidity in the stomach, leading to symptom relief and healing of ulcerative conditions.

Usage:

• Famotidine tablets should be swallowed whole with water, preferably before meals to maximize efficacy.
• It may be taken with antacids if needed, but it is advisable to avoid taking them simultaneously to prevent interference with drug absorption.

Dosage:

• The recommended dosage of famotidine varies depending on the indication and severity of the condition. It is typically administered once or twice daily.

Side Effects:

• Common side effects of famotidine may include:
  • Headache
  • Dizziness
  • Fatigue
  • Constipation or diarrhea
  • Nausea or vomiting
• Serious side effects such as allergic reactions or changes in liver function tests are rare but may occur.

Experience the effectiveness and reliability of AIT Pharmaceuticals Division’s Famotidine Range in the management of acid-related disorders. For more information, please contact us.